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Vetoquinol Zylkene Calming Support Supplement for Small Dogs and Cats 75 mg

Help your mildly to moderately anxious dog or cat relax naturally with Zyklene. For everything from noise phobias, travel, vet visits, and more!

$17.99$108.77

Description

Dogs and cats with mild to moderate anxiety often need support to help them relax.  Zyklene is an all-natural supplement that provides that support. It is one of few clinically proven natural anxiolytics.  Therefore, I can confidently recommend it to pets.  Not all dogs and cats respond to medications the same way.  You start to supplement with Zyklene several days before a stressful event, such as moving, vet care, Independence Day and New Year’s fire works, bad storms, etc.  If your pet’s anxiety is random or daily, Zyklene is safe for daily use.  It is not a sedative, your pet will not get drowsy while taking Zyklene. 

Clinical Trials:

https://www.sciencedirect.com/science/article/abs/pii/S1558787807002031

https://zylkeneusa.com/wp-content/uploads/study-beata-anxiety-in-cats.pdf

From the brand

  • Help Your Pet Cope With External Stress: Zylkene helps your pet cope with changes in their daily routine, such as travel, celebrations, vet visits, home alone, boarding, loud noises, and more.
  • Alpha-Casozephine: A naturally occurring milk protein found in cow’s milk that helps promote calming effects in your pet without drowsiness or other side effects found in other calming chews for dogs.
  • Lactose-Free and Easy on Sensitive Stomachs: Zylkene’s dog and cat calming supplements are lactose-free and made with natural ingredients that are easy on sensitive stomachs.
  • Veterinarian Recommended Daily Calming Support: Zylkene promotes calming in dogs and cats and can be given daily for behavior support and to help deal with unexpected external stresses.
  • Easy to Administer: Open the capsule of Zylkene and add it to your pet’s food daily to help them cope with external stresses like separation and improve daily behavior.

Additional information

Size

14 Capsules, 30 Capsules, 120 Capsules

Date First Available ‏ : ‎

July 2, 2019

Manufacturer ‏ : ‎

Vetoquinol

ASIN ‏ : ‎

B07S5KTWLQ

Best Sellers Rank:

#20 in Dog Relaxants

Customer Reviews:

3,005 ratings

60 reviews for Vetoquinol Zylkene Calming Support Supplement for Small Dogs and Cats 75 mg

  1. C. C. Selavy

    3.0 out of 5 stars

    No Effect Yet

    The capsules are easy to open, and my cat doesn’t seem to notice any flavor. He’s picky. He’s also a fairly recent adoptee (7 mo) who has been marking his territory daily. I also have one of those Zylkene dispersers going 24-hours and I’ve been using that and giving him Zylkene powder for about a month. They have not had any effect on his behavior so far, but I remain hopeful.

  2. Nancy

    4.0 out of 5 stars

    Seems to work

    I am not full dosing (partly because I missed a few days putting it in food she didn’t like) but do see a positive difference in her behavior. Maybe due to time. Wish I had known about this right at adoption. After struggling for 2 months, tried this on advice of feline behaviorists. Others suggested Feliway after a week and it helped, but not enough.

    2 people found this helpful

  3. Tamara Dunham

    5.0 out of 5 stars

    Recommend by Vet

    Product came as expected. Great tool in my arsenal for making sure my cat stays relaxed.

  4. Spooky

    5.0 out of 5 stars

    Must taste pretty good

    The cats will actually eat this and that’s most of the battle won! First thing I’ve ever tried for anxiety that they will actually eat. Sprinkle it on and stir it into the food. If they see it they think you’re trying to poison them but if you stir it in something they like, they’ll lap it up. Really seems to take the edge off. I have already purchased a second pack

    2 people found this helpful

  5. TaddHouse

    5.0 out of 5 stars

    This is working well to reduce aggression in our multi cat family

    It is helping us with a tough situation. Our youngest male cat and our youngest female teamed up to hassle, hunt, and attack one of the female cats in our house. She suffers from trauma from a previous bad situation she was in so she is easily startled and will jump and run hysterically through the house. It was getting worse and worse no matter what we did (play therapy, separating them, etc.). We started giving all 3 of the affected cats one capsule of this every morning and evening, in a churu treat. They readily lap it up, and the problem is much diminished. This is expensive so we tried to wean them off after one bottle but the hunting and harassment started again so we are giving it more time. The anxious cat is much calmer, in general. I am hoping that eventually they will get used to living together more harmoniously and we can stop.

    16 people found this helpful

  6. Sheila

    4.0 out of 5 stars

    Has definitely helped!

    I have 6 cats and one in particular was constantly stalking another one! There was not a day that I didn’t have continous fighting and chasing. The stalker is a big guy ( 17lbs) so I needed to give 2 capsules daily. I ended up sprinkling a capsule over his dry food morning and evening. He didn’t hesitate and accepts it. It hasn’t completely stopped his aggression, but I would say 75% success! That’s huge in my book.

    8 people found this helpful

  7. B.Laurie & M. Friesen

    4.0 out of 5 stars

    Appears to be working 🙂

    I purchased this item on the advice of my vet to help deal with my two cats. The cats are twin siblings (male & female) and have lived together in harmony until this past year (now are 8 years old). There has been a recent trigger with a new cat moving in next door last summer who has tried to insinuate himself into our household. Around that same time our female cat had become anxious and our male cat started to pee inappropriately in the house. I took both cats in to the vet to confirm no pathological reasons for the recent behavioural changes, then purchased this product to try.

    5 people found this helpful

  8. Scout

    5.0 out of 5 stars

    Really works

    I have tried a lot of different “calming” chews and/or products that are supposed to keep my dogs calm during stress but haven’t had much luck until I found these pills. I used them during fireworks this year and it helped my dogs so much. They are small terrier mix dogs and they are usually a wreck for hours and hours on the 4th but after taking these for a few days they were calm! One dog even slept through them! I was so relieved and so happy. I will keep using these. I broke open the pills and mixed the power with peanut butter and had no problem getting my dogs to eat it. It seems to have very little taste or smell. It seems to work best when taken daily or several days in a row. I highly recommend this product!

    6 people found this helpful

  9. Diana

    5.0 out of 5 stars

    Great calming sleep aid gir my doodle

    It is a healthy approach to calming down a pup.

    One person found this helpful

  10. tiffany

    3.0 out of 5 stars

    For anxious cats

    I give this to my cat because she’s easily anxious. When she gets anxious she has a ‘meow attack’ and will meow until someone calms her down (either by holding her or petting her until she calms down).This is how it works for my cat:Day 1 of zylkene – cat is still stressed, meow attackDay 2 – cat is still stressed, meow attack BUT slightly calmerDay 3 – cat is calmer & meow attack doesn’t last as longDay 4 – cat is calm, no meow attackDay 5 (no zylkene) – cat is back to being highly stressedShe would need Zyklene everyday in order to be calmer but I hate medicating her so often. Even though zylkene is natural I’m fearful of any LONG TERM side effects.And for those that are curious – those calming sprays do work but you have to spray the same amount you would if you tented your home for termites. The instructions on the bottle versus the amount you have to spray for a cat to feel calm are very different.I will continue to buy this though because it does work it just takes time. Immediate results shouldn’t be expected with something natural.

    16 people found this helpful

  11. Love is the ultimate trip

    5.0 out of 5 stars

    Works for my kitty (I think)

    My now 16-year-old kitty lost her companion kitty of 12 years in 2021. She has always been anxious, but it had gotten worse by excessively grooming herself and being agitated and unapproachable at her vet visits. Also, she has liver issues that pilling her for was nearly impossible. She fought me daily to the point of my saying that the stress it caused both of us couldn’t possibly be worth it. After stopping and then having labs done that showed little change in her liver values, the vet suggested that her anxiety could actually be the cause for that problem. Her vet suggested Zylkene as part of her regimen to calm her and keep her more comfortable when I’m away from home. The excessive grooming has stopped while I’m home. Whether or not that’s due solely to the Zylkene or other things that are being done I really can’t say, but at least the Zylkene is easy to give her where other meds have always been a major struggle. This is a capsule that can be opened and stirred into wet food. It’s undetected by my fussy eater. She hasn’t been back to the vet yet so can’t report on that part of the issue.

    3 people found this helpful

  12. Kindle Customer

    5.0 out of 5 stars

    Calm Without Drugs

    I live near a military installation with a lot of jet noise some days. If a vet visit coincides with one of these times, one of my cats will over groom and pull tufts of hair out and bullies my other cat. This product, sprinkled on food really takes the edge off the fearful stress that causes the behavior.I do have pheromone diffusers going as well, but this product has been a welcome addition for rough weeks.BTW, apparently the taste is good, they lick their bowls clean when it’s on their food.

    8 people found this helpful

  13. SWM

    5.0 out of 5 stars

    Recommended by Shelter Manager

    Easy, convenient way to calm pets.

  14. DaleDale

    5.0 out of 5 stars

    Successful

    This is just what we needed to calm this girl down! She used to attack me when her mood struck! I give her a capsule daily. She’s calmed down a lot !.I highly recommend this product!

    3 people found this helpful

  15. ReviewCritic

    5.0 out of 5 stars

    This is the only thing that calms my anxious cat

    My male cat was bullying the female cat when she was using the litterbox. So she stopped using it. I got her to start using it again by moving it out into an open space, I think she felt trapped in the bathroom when he would come in there. She wouldn’t urinate in it though. No matter what I tried. I took her to the vet and they gave me a long list of products. So many go in her food, and she immediately can tell and turns up her nose at it. This either has a taste she doesn’t mind, or it’s tasteless and it works! I had a hard time figuring out the right dosage because she’s large, but I finally got her peeing in the box again, and she’s just a much more calm cat overall. I also have a lot of Feliway diffusers. I notice that seemed to have a calming effect as well, but I don’t think they are strong enough for her without the Zylkene. Sadly, it’s a little on the pricey side. She needs about 300 mg a day. I give 1 small pill to the male cat too and it seems to keep him from picking on her so much.

    6 people found this helpful

  16. HollyL

    4.0 out of 5 stars

    Seems to be helping

    Bought this on a recommendation for my anxious dog. The pills seem to be helping. Wish the price was a little more reasonable because he needs to take 2 a day so they don’t last long. But it arrived fast and we’re happy with it.

    2 people found this helpful

  17. Bonita W.

    5.0 out of 5 stars

    They work

    I have a new young cat and an old cat the cat behavior list recommended these. I do not use them daily. I use half at one time.

  18. Jen

    2.0 out of 5 stars

    Pilling the Cat

    I wish my cats would let me give them a pill without being shredded. I also tried to mix this with tuna, and fancy feast cat food, but I guess it must have a strong taste. If you have no trouble “pilling the cat” it could be a great product.

  19. KZORBZ

    5.0 out of 5 stars

    Life Changer

    I rescued a male tabby cat at five months old (he’s now five years old). Since the inception, he’s had behavioral issues. He was very aggressive, never slept, overtly territorial, overate, vomited regularly and would attack out of nowhere (caused several deep bite wounds, two of which nearly landed me in the hospital). Not wanting a cat like this, I knew if I surrendered him, he would be euthanized, especially due to his history of biting.Having ruled out any underlying medical issues with his veterinarian, as a last resort, I consulted with a behavior specialist who felt he suffered from separation anxiety and she recommended Zylkene 75mg 1-2x per day.My cat has been on 75mg 2x a day for exactly one month today (he’s 16 lbs so the 75mg twice a day is appropriate dosing). After two weeks, I noticed my cat seemed considerably more relaxed. His sleep improved greatly, he’s no longer aggressive, has not vomited once, no longer overeats, is no longer territorial and has not even come close to biting me.He tolerates Zylkene well and administration is easy; I open the capsule and sprinkle the powder on top of Blue Buffalo moist food morning and night. I don’t need to mix it because he likes the taste of Zylkene; he licks the powder off the moist food prior to eating.The behavior specialist said I can ween him off this natural medication after a couple months, but quite frankly, I think it will be part of his daily regimen for as long as we are together.It’s very obvious my cat is much happier and more relaxed on Zylkene (without compromising his unique personality). Understandably, this makes me very happy because I just want to give him a happy, healthy and long life.UPDATE: It’s been over 3 months since my cat has been on Zylkene 75mg 2x day. Still no aggression or biting or any other related unwanted behavior. He has vomited a few times since my initial post but I narrowed that down to him inhaling the moist food when I sprinkle it with Zylkene morning and night. The resolution? Cutting the moist food down (from 3 oz to 1 oz per dose). He overtly loves the taste of Zylkene and loudly reminds me when it’s dosage time.

    78 people found this helpful

  20. E. L. Adams

    3.0 out of 5 stars

    Didn’t see any effect

    Bought it for a cross-country drive with a dog & cat, but I didn’t see any effect when they took it. No side effects though, so I gave three stars for at least not being harmful to my animals.

    2 people found this helpful

  21. Suz

    3.0 out of 5 stars

    Suggested by my vet, but did not work as well as needed

    My dog has extreme separation anxiety, tearing the fur from his paws, biting the cage and whining incessantly. Tried these for for 30 days and they did not work for him. I needed a quick acting sedative (Trazadone) to use for acute onset. Hopefully these will work for more mild cases.

    3 people found this helpful

  22. moiv

    5.0 out of 5 stars

    The good news and the even better news

    One of my two 8 year old blind cats has IBS, which of course is exacerbated by stress. Like most people who have reviewed Zylkene, I noticed a fairly quick improvement, and slurping up his daily dose mixed with a Delectables Bisque treat is the high point of Sammy’s day.Now for the even better news. While deep-diving for more information on the active ingredient, I learned that human-grade alpha-casozepine is patented by a French company as Lactium® — and that Swanson sells 60 capsules of 167 mg Lactium for about $10 less than 30 capsules of 75 mg Zylkene. If you have a 10 lb cat, that means Swanson Anti-Stress Formula gives you four times as many doses for 2/3 the price.Sammy and I are both pretty happy.

    30 people found this helpful

  23. G&P

    4.0 out of 5 stars

    helping reduce (but not eliminate) unpleasant feline behavior

    Vetoquinol Zylkene Calming Supplements for Small Dogs & Cats Up to 22lbs, Helps Relieve Dog Anxiety and Cat Anxiety, Non Drowsy, 75mg—Purchased at recommendation of our vet and now well into second bottle. Initially had concerns about it being a milk product in case he was allergic, but that has not been an issue. We mix the capsule in his wet food and he doesn’t even notice. Most of the time he gets mildly hyper after having his Zylkene but typically within 1-1.5 hours he calms down and snoozes. Overall, he seems calmer and more content. Definitely worth a try, especially if your vet recommends it for your furbaby.

    6 people found this helpful

  24. Amazon Customer

    5.0 out of 5 stars

    It Works!

    This has made a huge change with a terrified, shut down foster dog. And it only took a week to start seeing results.

    2 people found this helpful

  25. Susan F.Susan F.

    5.0 out of 5 stars

    I’ve gotten great results with Zylkene

    This product has really helped my new dog’s anxiety, which was off the charts. I’ve had better results with this than CBD oil. It takes three to four weeks to start seeing effects, so it takes a little patience, but for my girl, rescued from a hoarding situation, adopted, and then rehomed to me a few months later, it’s been amazing. I’m told it doesn’t work for every pet, but when it does, wow! I just break open a capsule once a day and sprinkle over her wet food. It’s tasteless and odorless, so no chance she’ll turn up her nose at it. Highly recommend.

    7 people found this helpful

  26. Dottie Haxton

    5.0 out of 5 stars

    quality

    as expected

  27. Kathy Albert

    5.0 out of 5 stars

    Great Equalizer

    Really calms our kitty when he’s stressed.

    One person found this helpful

  28. Linda

    3.0 out of 5 stars

    Not for diabetic cats

    Zylkene is expensive but it did seem to be helping my cat a bit. However, I just ordered another bottle and realized that it contains maltodextrin. I missed this ingredient the first time. My cat has diabetes and maltodextrin spikes her blood sugar. Now I can’t give it to her anymore and I’m out the money. Wanted to warn others in case they have diabetic cats, too. I feel bad that I have been contributing to her blood sugar problems.On the plus side, it seems to be tasteless since I sprinkle it on my cat’s food and mix it in. She eats the food without hesitation.

    6 people found this helpful

  29. Liz Kurincak

    5.0 out of 5 stars

    It helped our 10 year old dog to not be so reactive to sudden noises or movements

    To help our dog be more relaxed

    One person found this helpful

  30. Melissa BrMelissa Br

    5.0 out of 5 stars

    Helped my small dog

    This seems to take the edge off my Chihuahua’s anxiety and fear. Before taking this product he was barking and growling at people and dogs while on walks and hikes. He has since stopped. He’s only been on it a few days but i noticed a difference right away. I also do behavior modification, he sees a person or dog & he gets a treat but that alone wasn’t cutting it. He still notices noises at home but is less reactive than he used to be. Overall he is a bit more chill. I will definitely be keeping him on this

    7 people found this helpful

  31. Alice Coburn

    2.0 out of 5 stars

    Worked well; wish it wasn’t a capsule

    On our test run of the product to see how my cat would react to it (a few days ahead of time), we were able to sneak it in her food for those administrations of it. Unfortunately she’s able to detect anything funky, even in the stinkiest of cat treats or foods! She wouldn’t eat the whole thing, even though it was the same treat she had daily and always devours. The day of our move, we had withheld food so that she would *definitely* eat it and she would be less likely to get car sick. Again, didn’t have good luck with her eating it. She had maybe a couple of licks, turned her nose up, and tried to find food hiding somewhere else instead. Even though she didn’t eat much of it, on the trip she threw up what little she had eaten and some bile within 2 hours of our 7 hour move. Luckily I was able to stop at a pharmacy and get a needle less syringe, mix the inside of the capsule with some water, and basically force it down her (which I hate to do). We waited a while for it to take some effect, but ultimately she threw it up within about 15-30 minutes. I wish it was an actual pill instead of a capsule. There’s just so much medicine in the capsule that my little cat can detect it, no matter how much food I give her with it or what treats I use. It would be so much easier to be able to just give her a pill instead. I hate giving her liquid meds because of how violent the process is. The only reason we even tried this was because it was highly recommended by her vet. Next time I’ll experiment with more natural options like kitty CBD or I’ll stop by a vet the day of the trip and get something better.

  32. LWOOD

    3.0 out of 5 stars

    Not what I was hoping for

    Vet recommended this for anxiety for my yorkie. Did 2-3 months and noticed no improvement.

  33. Cassie F.

    3.0 out of 5 stars

    Unsure

    So hard to pill my cat, I can’t really monitor how much she gets. Shipping quick!

  34. Quasar

    5.0 out of 5 stars

    FOR ANYONE NEW – YOU PULL APART THE TABLET AND SPRINKLE POWDERED CONTENTS ON WET FOOD AND MIX IN!

    This product is absolutely amazing and works better than anything else. Please make sure you pull the tablet apart and sprinkle contents on wet food and mix it in their wet food. They won’t know it is there. The product works pretty much instantly or within 5 or 10 minutes. You animal will be super chilled out! Warning: if giving to cats or small dogs – start out by giving half a pill… just open the pill and sprinkle half, then reseal the pill together again. It’s easy to save half for later – just put the pill back together and save for next time. This stuff is powerful and half a pill may make your animal a chilled out little zombie, so be careful not to give a full dose the first time as half may be all you need. If you are going into an extremely stressful situation like moving a cat in a car and the cat hates it, then give a whole pill. Just be aware that half a pill will work most of the time. This is one of the best products I’ve ever used and I only use it when needed. I don’t use this every day – but it’s perfect to have on hand for when you need it.

    22 people found this helpful

  35. CBest

    4.0 out of 5 stars

    Worked at home BUT not at Cat Show

    I gave this item 4 stars because it did calm my show cat at home. However, when I took her to a cat show she still hissed at the judges. I think this works under normal circumstances, is easy to give as it is a tasteless powder that they lap up in food, but did not make my feisty Norwegian act like a docile persian in the show ring.

    5 people found this helpful

  36. MOMof3

    5.0 out of 5 stars

    Game to try anything…

    So, we are a 3 cat full time household and a part time household of 2 additional cats. All of our cats are rescues. One of my full time cats has sever anxiety, sever! One of my part time cats flies back and forth from California and although he knows his environment it still causes a lot of stress and anxiety for him. Our other part time cat is a college cat. He’s disabled and does not adapt to car rides, new people or change. His anxiety triggers bladder irritation. So our vet suggested trying this supplement. I LOVE IT!Pros: completely calmed my highly anxiety cat, our California cat was so much more laid back and handled the plane ride like a pro and our college cat hasn’t had another bladder flare up. Easy to administer. Just dump capsule contents into moist food and mix well.Cons: it’s super expensive for a 30 day supply, especially if you consider my two part time cats are both big boys weighing in over 15lbs a piece and they need two pills per dose. So we don’t use it full time. Anxiety cat gets it when people are staying with us or the part time cats are home or when we go on vacation and the pet sitter is there. California cat gets it a couple days before and after he comes and throughout his stay with us. College cat gets it during any and all environmental changes or any significant change in general.I know not everyone has had success with it, however, we have and will continue to use it.

    10 people found this helpful

  37. Defyxinfinity

    4.0 out of 5 stars

    Seem to work but can’t confirm; cheaper than the vet

    These are priced cheaper than at any vet’s office I checked, and it’s the same legit product. You don’t need an Rx (contrary to what one vet tech tried to tell me) and it’s easy to administer. I break open a capsule and sprinkle it onto my cats food, ill put a small amount of food to be sure they’ve finished the whole dose in case the other cat tries to get to it since he doesn’t need it. I regret not trying it for my very anxious dog with all of the recent fireworks, but it’s safe for dogs and cats up to a certain weight. Not a ton of capsules in a package so only use when you really need to.

    7 people found this helpful

  38. johnthebaker

    4.0 out of 5 stars

    Recommended by a Behaviorist for Calming

    This product was recommended by a behaviorist for our cats. This was not an online behaviorist – but an honest to goodness in-home visit. We use Zylkene in conjunction with calming collars and prescription dry kibble for calming as well. The aggressive cat (suffers from fear anxiety) also gets Fluoxetne. It’s tough to say if Zylkene works as we’ve got so many things working at the same time. It was a necessity however – two cats that loved one another as best buddies took an ugly turn in July 2017. We needed help because the aggression was over the top to the point where we constructed a 48″ high gate system in the house. No kiddie gates were going to keep these two apart – there was stalking involved early on. We were told by another behaviorist (with no empathy or bedside manor to speak of) that they’d never come together if there was stalking involved. So we started with Prison MAX for cats (gates), hired a more empathetic behaviorist for a game plan and moved on.We’ve been using Zylkene at night – last feeding of the day – sprinkled in a small serving (2 TBSP.) of wet food as a treat for both cats. The cats either like the taste or cannot tell that it is there. We have been using this for about eight (8) months. My only gripe is the capsules. To get at the product you need to empty the capsules which is a pain. When you’re pouring them out onto the food – you are pinching the capsules to keep a grip – this keeps product in the back of the capsules on occasion – it’s not all delivered to the food. It would be great if they could put the powder in a wide mouth container and include a measuring spoon that was equal to one (1) capsule. Make it double sided with a two (2) capsule serving n the other end for bigger pets. It would save wasted capsules for one thing and you wouldn’t be fumbling with these, trying to keep a grip and shake them out. Sounds like a petty gripe – but if you are stressed out and need to open four of these things fast – it could be more user friendly.Does it work? Again – tough to say with everything going on (collars, prescription diet, training etc.) – but after nearly 10 months of this – we turned a major corner recently. Keep in mind that it’s all about changing behavior which is easier to do if they are calm. We also click train now, use scheduled feedings (no free feeds) and tons of praise, play time and patience.We are giving the product the benefit of the doubt and will continue to purchase and use it as part of the ‘cocktail’ approach.If you are having similar issues my heart goes out to you. Hang in there and don’t give up.

    39 people found this helpful

  39. Robbie Wood

    4.0 out of 5 stars

    Finally has 3 new feathers!

    My parrot has been feather picking for YEARS and my avian said to try this product.I’m going into my 3rd month and she has 3 new feathers that she has not picked out. I’m thrilled!!Reason for 4 stars instead of 5 is the price.

    One person found this helpful

  40. oteeka davis

    4.0 out of 5 stars

    Hyper Cat

    I bought this item hoping it would calm my Siamese cat down. It was a long shot and it doesn’t reflect on the item’s actual results. My cat is just very different. He hides, he darts from place to place, can’t touch or pet him; he’s a loner. He has gotten worse since we had to put down his buddy. So, I just live with a weird cat.

    4 people found this helpful

  41. Recurring customer

    5.0 out of 5 stars

    They help my cat.

    My cat is older and has some kind of a condition where her pupils in her eyes don’t go down to normal. Little is known about this condition. It happens in some older cats and brought on by trauma or stress. We had two cats and she grew up with him and always together. He had died after years and she was depressed and it brought on this condition. She hides in dark places because of her dilated pupils. She is always afraid. We got another cat a few years ago and he was an older kitten but he picked on her and she was constantly chewing herself and excessive grooming and she was chewing out her own fur. We had moved also so several things happened to stress her and little is known about the condition. She would switch her tail but the nerves are sensitive in her back near the tail end it causes her to switch her tail. I was at wits end with her. She is older. 13 yrs old now, but she was in horrible shape. She itched, chewed and it was almost like self mutilation. I read about this condition on Google and I understood much of what I was seeing in her. Stress had brought it on.So I have used this product for two days now. She is calm. She is not itching. She has stopped chewing out her fur. I have noticed small differences in her from before. She is gained an appetite back that she had lost. She had lost weight and she wouldn’t eat. Her appetite is back. It’s good to see her eating again. Her pupils are not quite so dilated as they were. She still hides but she will lay by another cat we took in a couple years ago. She sees him as a protection. She had stopped going outside for years. Because of the dilated pupils. She would go out seldom at night. But the pupils were looking slightly better and she had went outside for the first time in years. She is calm but not sleepy. She has stopped chewing out her fur. She is not so afraid as what she was. She still hides but not as much. She is not switching her tail constantly and her back end nerves seem better. She had been in misery. She is calm and I am very slowly seeing her return to not normal but she has greatly improved. Her laying by another cat at night without being afraid is something. She didn’t do that and I watched her go down hill for years. I was desperate to find her help. Vets didn’t seem to help except to empty my wallet on skin testing and blood tests. The vet didn’t even know what it was. But it was brought on by the severe stress. I ended up reading about it online searching for anything because the vet drained me dry only to know nothing. One online did recognize the condition which I can’t remember the name.But the pupils are getting better. Not normal but she went out during the day for the first time in years. They are slightly better than they were.She’s stopped chewing out her fur. She’s not itching anymore and the scabs around her neck are better. Because she isn’t constantly scratching her neck now. I spent money trying to find something to help her and I saw nothing. Nothing helped. But this has helped tremendously in just a couple days.She is calm now. She will still go into hiding but I have seen a small improvement. She was able to lay by another cat. So there is improvementThe slightly different pupils were a good sight to see. They were constricted a little. So she was able to go outside for the first time in years during the day.She still hides but not quite as bad. She will come out of hiding some now.The nerves and tail switch has dramatically improved and she had not been able to jump anymore and she had fallen off things. She did climb the back fence outside. She still climbs but she is not so unstable as she was. She did jump once but not far but at least she has balance now and the back nerves have improved.This stuff has helped so much in just two days time. It is giving me back my cat and giving her back a slightly normal life that she didn’t have before. She has been able to stop the self mutilation of chewing her fur out and skin is better. I don’t think that they are supposed to take it every day so I am going on a once a day but if needed. I saw such a difference from the way she was so I ordered more. I will keep it on hand for her. She didn’t get sleepy or drowsy but she was just totally calm. What ever the condition is its brought on by stress. But it is slowly giving her back a better quality of life. Helped me out just to see her being so much better. She eats the stuff well mixed with her cat food. She seems to like it. Normally she will turn away from anything in her food so she must like the taste. .If you ever have a cat with whatever condition this is, try this. It does help tremendously. I am seeing such differences in her behavior and it’s all positive. So glad to have tried this stuff out. This is be a life changer for positive when you have a cat severely stressed out. I am thankful to have read about it. It’s been a positive experience in the changes I’ve seen in two days time.

    60 people found this helpful

  42. Raymond J. Toth

    5.0 out of 5 stars

    Recommended by me Vet

    Give it to my dog at night. Helps keep him calm overall.

  43. Greg Adkins

    4.0 out of 5 stars

    Works well with our Yorkies

    Works well with our overactive Yorkie

    3 people found this helpful

  44. Charlotte

    5.0 out of 5 stars

    Actually Effective & Cats Enjoy the Flavor

    My boyfriend and I have 3 cats. 2 of them, Gus and Alfador, used to be best buddies, but after a fateful vet visit 5 months ago, they couldn’t spend a few minutes together without trying to eviscerate each other. At a follow-up visit, the vet suggested Zylkene as a last ditch effort before Prozac. Additionally, the vet suggested administering Zylkene to Gus (a.k.a. the victim; cats don’t care about political correctness). Ironically, our third cat, Penny, is terrified of Gus, so we have been giving Zylkene to her as well.I was very skeptical of this product, especially after my boyfriend went online to research the benefit of casein and only found studies about muscle building. I was also very doubtful that Penny and Gus would eat food dosed with this because they are fussy eaters. However, they not only eat wet food mixed with Zylkene but seem to eat it with extra enthusiasm. (I did taste it–it’s lightly salty, with just a hint of bitterness, so perhaps the cats enjoy the salt).Better yet, it is making a big difference in our household. The impact seem to be minimal for Penny (age 5), but Gus (age 16) has responded very positively. His stress around his aggressor has decreased to the point that, while Gus remains timid, he and his brother can stay in the same room without any fights erupting. I am very hopeful that they’ll be curling up again together soon, and I can’t emphasize enough how much of a relief that is after months of separating them.

    16 people found this helpful

  45. dailyreader

    3.0 out of 5 stars

    Decent product but the constant price increases force me to look for alternatives

    I have a small terrier with allergies and anxiety. For her to be happy, I have to manage both. This product does a good job of relaxing her, though it is not the only thing I use. I do notice when I stop using it she is antsier, so I have chosen to continue the product. But the price continues to increase from expensive to untenable. I looked around for alternatives.The active ingredient is called Alpha-Casozepine, according to the label. So, in looking for products with this, it turns out that Lactium is a trademarked version of this. It was difficult to find a product with this alone. Ultimately, I found a Swanson Antistress human product that contained only this as an active ingredient. There are other products that have this ingredient along with other things that I didn’t want. I’ll see how this new product works once I receive it.Interestingly, Calmkeen, a product that markets itself as similar, has hydrolyzed milk protein as the active ingredient, but it does does not have the actual Alpha-Casozepine. I bought it to alternate with Zylkene, but it simply does not work as well for my dog. And the price, which is significantly cheaper than Zylkene, has continued to rise likely because Zylkene’s has. Anyway, if money is no option, then Zylkene is an effective product. If you don’t want to continue to pay chronic price increases, you may need to look for an alternative.

    23 people found this helpful

  46. Jessica L.

    5.0 out of 5 stars

    Decided to revisit this and try it out again

    Update 7 days after initial review:I have been giving 1/2 of a 75mg capsule twice a day to my cat for 7 days straight now and she has not attacked my other cat in 7 days! We usually have stalking and attacking constantly so to go from constantly to none is very impressive! What I really like is that she still has her personality and does not seem drugged in any way. She just isn’t a psychopath stalker anymore 🤷🏻‍♀️. I plan on continuing the regimen and giving 1/2 to her twice a day. I started by sprinkling half a capsule on her wet food but she doesn’t eat all of it (she doesn’t mind the powder at all) so instead I have been buying pill pockets and I just knead it into the pill pocket like a dough and she eats it right up. This way she gets the full dose and I’m not wasting any.Initial review:My vet recommended that I try this before we put my cat on Prozac.I have two cats. My cats are not litter mates, they are both 6 years old and I adopted them one year apart. Pandora was the second cat I adopted and she has turned out to be a little psychopath. She constantly bullies and stalks and chases and attacks my other cat. It drives me insane and at times it’s extremely draining. I have tried very good quality lab tested CBD, and every kind of feliway spray and diffuser there is. Nothing works.I purchased this about 8 months ago and the first time I gave it to her she full on attacked my foot (not playing, it was very aggressive) and she has never done that before. So I have not given it to her again.Out of desperation, I am revisiting this option, after reading more about how to administer, I think she probably just needs more time to adjust.I sprinkled half of one capsule on top of about a tablespoon of wet food. She ate almost all of it right away.I purchased some pill pockets and I think I can smush the powder into them and feed it to her that way to ensure she gets as much of the product as possible without wasting any.She goes crazy for pill pockets! I’ll gladly update this review once we finish the bottle.Tonight was the first night we started it again and she walked around the house looking for something to get into for about 30 minutes (typical) and then laid down and went to sleep.

    11 people found this helpful

  47. Sue

    5.0 out of 5 stars

    Kitty Prozac alternative

    A breeder suggested this option for my rescue kitty, and I’m so thankful! Couldn’t get him to take Prozac from the vet, but I open these capsules, sprinkle on his food, and he doesn’t notice. A real blessing if you’ve ever tried to give a cat a pill!

    3 people found this helpful

  48. christopher l arnold

    5.0 out of 5 stars

    Helps

    It does seem to help and he continues to eat it so I continue to buy it.

  49. Marissa Medina

    4.0 out of 5 stars

    Totally recommend

    Has definitely help my catShe is more comfortable and social

  50. CM

    5.0 out of 5 stars

    Helped calm my bully cat.

    Our one male cat gets in his moods and chases or stares down the other two cats. Occasionally jumps on other males back pinning him to the ground. I have tried calming sprays, chews, plug in diffusers etc with little success. After reading the positive reviews, decided to try this. I started by sprinkling half of a capsule in his wet food in the morning and it calms him right down, the bully behaviors are all but gone and the other cats are moving around the house more freely once again. I waited few weeks to write this review to be sure it wasn’t my imagination or a fluke but am so glad I tried this product and highly recommend.

    18 people found this helpful

  51. Eliza M.

    5.0 out of 5 stars

    It actually works!

    I was skeptical about this because it is just milk protein – and whoa! the price – but it was totally worth it. Sprinkled it on my first cat’s food and he never noticed it. In a couple of days, I noticed he calmed down just a bit. It’s subtle, but still worth it while he dealt with adjusting to a new cat in the house.

    3 people found this helpful

  52. Laura

    5.0 out of 5 stars

    changed my kitty’s life

    One of my cats, after I adopted her, was such a darling little diva. She was awesome. She was Liza Minelli as a cat (minus singing). However, after I fostered a momma cat and ended up keeping her and a baby, Izzy, started getting anxiety. That first bout, we solved with Prozac as she was licking the fur off of herself. After 2 months on it she was good. Until about a year or so later when one of my other cats started bullying her. For many months, she grew nervous about using the litter box (afraid she would be attacked), she stayed in 1 or 2 cat trees, she was not herself. My vet started her on this and in about 2 weeks, things started changing. It wasn’t all of a sudden, but over the course of a few months, my girl changed. She has been on this med for about a year now. She no longer hides in a cat tree, or just in one part of the house, she is out and about, on my lap, she doesn’t run from the other cats, she has her confidence back. She doesn’t alert me to when she needs to use the litter box so that I can guard it any more, but she still lets me know when she has to “go” if the box isn’t clean enough for her or if she wants me to put her into her room for the night so that she can “potty in peace”. There are no side effects to this medication. It’s a milk product that according to my vet either works or it doesn’t. For my girl, it has worked.

    16 people found this helpful

  53. Ana Mardoll

    5.0 out of 5 stars

    Anxious Kitty

    Vetoquinol Zylkene Behavior Support CapsulesWe bought these for our cat, Cookie, because she’s an anxious baby with a traumatic past. Her anxiety was causing her to patrol the house at night, keep watch at the windows, and yowl whenever a neighbor walked their dog. (She’s scared of dogs, due to a prior trauma.) Our vet suggested that we give her these. She’s hard to pill but she likes to lick up the gravy that comes with soft food, so we open a pill and shake the powder into the gravy and stir it up. She licks it up just fine and doesn’t seem to notice or mind a taste. It really does seem to calm her down; she still walks and plays, but she isn’t quite as anxious and nervous if that makes sense. I wish these were a little cheaper but a dollar a day isn’t too much to pay for her peace of mind.~ Ana Mardoll

    7 people found this helpful

  54. Carla O’BrianCarla O’Brian

    4.0 out of 5 stars

    Has helped with litter box issues!

    This little sweetie Jojo lost his hearing and started pooping outside the litter box and spraying around the house due to anxiety. We tried prescription meds, but those just made him zombie-esque. Our vet recommended Zylkene, so we gave it a try. I mix one capsule with his wet food each morning and he gobbles it up. I saw an improvement in his behavior about 10 days after starting the Zylkene. I’m also using Feliway diffusers. The combination of the two has drastically improved his behavior. He now poops in the box 90% of the time and rarely sprays anymore. So far he’s been on this for almost three months. Im so glad our vet recommended this!

    16 people found this helpful

  55. Melinda Smith

    5.0 out of 5 stars

    IT. WORKS.

    My cat has feline hyperesthesia syndrome. She’s always been a little uptight but when she started doing the crazy twitching biting thing I was so sad. Honestly if it were a person you’d think meth head. This medicine was easy to sprinkle on her food. It didn’t make her seem stoned, it just made her a Calm Kitty and it worked pretty fast. How weird. Who knows how it works, and really, who cares. She’s happy, I’m happy.Zylkene, I believe a big chunk of your consumers are middle-aged women on a fixed income (not to generalize but I’m probably in the ballpark). The price is higher than my budget allows given I’ll probably be a repeat customer, but considering the emotional factor and the fact that it’s cheaper than a vet, ok ok I’ll buy it. But you knew that, didn’t you. I feel slightly manipulated, but I’m still grateful it’s out there.

    22 people found this helpful

  56. ef

    5.0 out of 5 stars

    Safe and takes the edge off

    I give this to my cats in Churu and they take it easily. I think it takes the edge off 🙂

    One person found this helpful

  57. Leslie LintonLeslie Linton

    5.0 out of 5 stars

    Relaxed Lucy Loo by Using Zylekene

    The product works fast & definitely calms our Lucy Loo when she has separation anxiety or is frightened by thunder. Capsules can be given easily either by slipping them down her throat or by opening the capsules & put them on your dog’s kibble. Better than using other calming treats.

    2 people found this helpful

  58. Amazon Customer

    4.0 out of 5 stars

    Calming

    Seemed to help my pet

  59. KarenKaren

    4.0 out of 5 stars

    Give it a week and see a change

    I was hesitant because it is pricey but desperate to try somehing to help our little runt kitty have more quality of life. He hid all day long. Would not let anyone hold him. He would smack his lips if you did hold him and then he would jump as fast as he could out of your arms. He was not interested in playing and all sounds scared him. After one week he has definitely made changes in his behavior. I just wish it was not so expensive.

    12 people found this helpful

  60. Kathleen Dulko

    5.0 out of 5 stars

    Works better than plugins!

    Purchased for calming effect while I integrate new cats. It hits each cat differently, but they all seem more calm and “open” to each other. More curious, less scared and aggressive. Works better than any of the calming treats, or plug-in things that I’ve tried.

    3 people found this helpful

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